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Arch Mal Coeur Vaiss · Jan 1991
Review[The role of the endothelium in the regulation of vasomotor activity].
- C Boulanger and P M Vanhoutte.
- Département de recherche, hôpital universitaire, Bâle, Suisse.
- Arch Mal Coeur Vaiss. 1991 Jan 1;84 Spec No 1:35-44.
AbstractThe classical physiological concept of the endothelium was that of a barrier and a surface of exchange. Little importance was attached to its role in the regulation of vascular tone. Successively, prostacycline, the endothelium-derived relaxing factor, the hyperpolarizing factor, the endothelium-derived contracting factor and especially endothelin, were discovered and their physiological effects are currently under evaluation. These different factors and their possible roles in vascular pathology are reviewed. The endothelial function or functions are probably abnormal in many pathological situations.
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