• Age and ageing · Mar 2006

    Case Reports

    Metformin-related vitamin B12 deficiency.

    • Kin Wah Liu, Lok Kwan Dai, and Woo Jean.
    • Medical and Geriatric Unit, Shatin Hospital, New Territories, Hong Kong, China. kwliuhk@yahoo.com
    • Age Ageing. 2006 Mar 1;35(2):200-1.

    AbstractMetformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.

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