• Br J Surg · Feb 1980

    Comparative Study Clinical Trial Controlled Clinical Trial

    Peroperative antibiotics in the prevention of chest infection following cardiac operations.

    • R B Galland, D M Shama, K B Prenger, and J H Darrell.
    • Br J Surg. 1980 Feb 1;67(2):97-8.

    AbstractSeventy-nine patients about to undergo cardiac operations were randomly allocated to two treatment groups in an attempt to reduce postoperative chest infections. The group receiving a short peroperative course of cefamandole, an antibiotic effective against both the pneumococcus and Haemophilus influenzae, had a significantly lower postoperative chest infection rate than the group receiving a 3-day course of cephradine, an antibiotic previously chosen to prevent intracardiac infection during the operation. By selecting an appropriate antibiotic it is possible, using a short peroperative course, to reduce the postoperative chest infection rate in patients undergoing cardiac operations.

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