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Anesthesia and analgesia · Jan 2016
Review Historical ArticleThe History of Target-Controlled Infusion.
- Michel M R F Struys, Tom De Smet, John Iain B Glen, Hugo E M Vereecke, Anthony R Absalom, and Thomas W Schnider.
- From the *Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; †Department of Anesthesia, Ghent University, Gent, Belgium; ‡Demed, Temse, Belgium; §GlenPharma, Knutsford, Cheshire, United Kingdom; and ‖Department of Anesthesiology, Intensive Care, Rescue and Pain Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- Anesth. Analg. 2016 Jan 1; 122 (1): 56-69.
AbstractTarget-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.
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