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J. Cereb. Blood Flow Metab. · May 2007
Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord.
- Yong Lin, Hendrik J Vreman, Ronald J Wong, Tjoson Tjoa, Toshihiro Yamauchi, and Linda J Noble-Haeusslein.
- Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143-0520, USA.
- J. Cereb. Blood Flow Metab. 2007 May 1;27(5):1010-21.
AbstractWe hypothesized that heme oxygenase (HO)-1, the inducible form of HO, represents an important defense against early oxidative injury in the traumatized spinal cord by stabilizing the blood-spinal cord barrier and limiting the infiltration of leukocytes. To test this hypothesis, we first examined the immunoexpression of HO-1 and compared barrier permeability and leukocyte infiltration in spinal cord-injured HO-1-deficient (+/-) and wild-type (WT, +/+) mice. Heme oxygenase was expressed in both endothelial cells and glia of the injured cord. Barrier disruption to luciferase and infiltration of neutrophils were significantly greater in the HO-1+/- than WT mice at 24 h postinjury (P
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