• Anesthesia and analgesia · Apr 2007

    Clinical Trial

    Co-injection of clonidine prolongs the anesthetic effect of lidocaine skin infiltration by a peripheral action.

    • Jayant Nick Pratap, Rajesh K Shankar, and Teodor Goroszeniuk.
    • Department of Anaesthesia, Guy's & St. Thomas' NHS Foundation Trust, London, UK.
    • Anesth. Analg. 2007 Apr 1;104(4):982-3.

    BackgroundThe addition of clonidine to local anesthesia prolongs the local anesthetic action, but in humans, the contribution of a peripheral mechanism remains unclear.MethodsWe investigated clonidine's peripheral effect in 20 healthy volunteers undergoing double-blind, subcutaneous infiltration of 0.5% lidocaine with normal saline to one forearm and then, immediately, of lidocaine with 10 mug clonidine to the contralateral arm. Pinprick sensation was tested every 15 min for 6 h.ResultsMedian time to return of normal sensation was 3.5 h for lidocaine alone, but at least 6 h if combined with clonidine (P < 0.001).ConclusionsClonidine has a significant peripheral action in enhancing duration of local anesthesia on superficial co-infiltration with lidocaine.

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