• Expert Rev Anti Infect Ther · Apr 2006

    Review

    Japanese encephalitis: development of new candidate vaccines.

    • Kaushik Bharati and Sudhanshu Vrati.
    • Virology laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, India. kaushik@nii.res.in
    • Expert Rev Anti Infect Ther. 2006 Apr 1;4(2):313-24.

    AbstractJapanese encephalitis (JE) is the most common form of viral encephalitis that appears in the form of frequent epidemics of brain fever throughout Southeast Asia, China and India. The disease is caused by a Flavivirus named Japanese encephalitis virus that is spread to humans by mosquitoes. An internationally approved mouse brain-derived inactivated vaccine has been available that is relatively expensive, gives immunity of uncertain duration and is not completely safe. Cell culture-derived inactivated and attenuated JE vaccines are in use in China, but these are not produced as per the norms acceptable in most countries. Several new promising JE vaccine candidates have been developed, some of which are under different stages of clinical evaluation. These new candidate JE vaccines have the potential to generate long-lasting immunity at low cost.

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