• Infect. Dis. Clin. North Am. · Mar 2011

    Review

    Central line-associated bloodstream infections: prevention and management.

    • David J Weber and William A Rutala.
    • Division of Infectious Diseases, University of North Carolina School of Medicine, 2163 Bioinformatics, 130 Mason Farm Road, Chapel Hill, NC 27599-7030, USA. dweber@unch.unc.edu
    • Infect. Dis. Clin. North Am. 2011 Mar 1;25(1):77-102.

    AbstractApproximately 80,000 central venous line-associated bloodstream infections (CLA-BSI) occur in the United States each year. CLA-BSI is most commonly caused by coagulase-negative staphylococci, Staphylococcus aureus, Candida spp, and aerobic gram-negative bacilli. These organisms commonly gain entrance in into the bloodstream via the catheter-skin interface (insertion site) or via the catheter hub. Use of strict aseptic technique for insertion is the key method for the prevention of CLA-BSI. Various methods can be used to reduce unacceptably high rates of CLA-BSI, including use of an antiseptic- or antibiotic-impregnated catheter, daily chlorhexidine baths/washes, and placement of a chlorhexidine-impregnated sponge over the insertion site.Copyright © 2011 Elsevier Inc. All rights reserved.

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