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Editorial Comment
A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
- Zbigniew Zasłona and Marc Peters-Golden.
- Crit Care. 2012 Jan 1;16(5):161.
AbstractNew therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.
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