• Crit Care · Jan 2009

    Comment Review

    Understanding the cognitive consequences of critical illness through experimental animal models.

    • Max Gunther and Brett English.
    • Department of Radiological Sciences, Center for Health Services Research, Vanderbilt University Medical Center, Vanderbilt Institute of Imaging Sciences, Nashville, TN 37232-8300, USA. max.gunther@venderbilt.edu
    • Crit Care. 2009 Jan 1;13(1):104.

    AbstractTuon and colleagues have developed an animal model to examine the impact of sepsis on memory in rats. They report important data that expand the understanding of the cognitive consequences of critical illness. Future research should follow this path of inquiry and extend animal models beyond aversive conditioning to include recently developed paradigms that will permit assessment of complex and cognitive processes, such as attention, episodic memory and orientation to time and place. This has the potential to greatly increase the putative understanding of the homologous neurocognitive dysfunctions acquired during critical illness.

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