• JNMA J Nepal Med Assoc · Oct 2010

    Randomized Controlled Trial

    Ketamine gargling and postoperative sore throat.

    • S K Shrestha, B Bhattarai, and J Singh.
    • Department of Anesthesiology, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal. drsantosh_shrestha@yahoo.com
    • JNMA J Nepal Med Assoc. 2010 Oct 1;50(180):282-5.

    IntroductionTracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sorethroat (POST). The aim of the study was to compare the effectiveness of ketamine gargle with placebo in preventing POST after endotracheal intubation.MethodsForty patients scheduled for elective surgery under general anaesthesia were enrolled in this randomized, control trial. Patients were randomly allocated into two groups of 20 patients each: Group C, gargling with drinking water 30 ml; Group K, gargling with ketamine 50 mg in drinking water 30 ml for 30 s, 5 min before induction of anaesthesia. POST was graded at 4, 8, and 24 hours respectively after operation on a four- point scale (0-3).ResultsPOST occurred more frequently in Group C, when compared with Group K at 4, 8, and 24 hours.ConclusionsKetamine gargle reduces the incidence of POST after endotracheal intubation.

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