• Intensive care medicine · Jul 1998

    Case Reports

    Survival in a case of life-threatening flecainide overdose.

    • N A Hanley, J P Bourke, and A D Gascoigne.
    • Intensive Therapy Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
    • Intensive Care Med. 1998 Jul 1;24(7):740-2.

    AbstractFlecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (< 0.1% of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.

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