• Angeliki Papadaki, Manolis Linardakis, Thomas M Larsen, Marleen A van Baak, Anna Karin Lindroos, Andreas F H Pfeiffer, J Alfredo Martinez, Teodora Handjieva-Darlenska, Marie Kunesová, Claus Holst, Arne Astrup, Wim H M Saris, Anthony Kafatos, and DiOGenes Study Group.
• Preventive Medicine and Nutrition Clinic, Department of Social Medicine, Faculty of Medicine, University of Crete, Greece, PO Box 2208, Heraklion 710 03, Crete, Greece. agpapadak@edu.med.uoc.gr
• Pediatrics. 2010 Nov 1;126(5):e1143-52.

ObjectiveTo investigate the effect of protein and glycemic index (GI) on body composition among European children in the randomized, 6-month dietary intervention DiOGenes (diet, obesity, and genes) family-based study.Patients And MethodsIn the study, 827 children (381 boys and 446 girls), aged 5 to 18 years, completed baseline examinations. Families with parents who lost ≥ 8% of their weight during an 8-week run-in low-calorie diet period were randomly assigned to 1 of 5 ad libitum diets: low protein (LP)/low glycemic index (LGI); LP/high GI (HGI); high protein (HP)/LGI; HP/HGI; and control diet. The target difference was 15 GI U between the LGI/HGI groups and 13 protein percentage points between the LP/HP groups. There were 658 children examined after 4 weeks. Advice on food-choice modification was provided at 6 visits during this period. No advice on weight loss was provided because the focus of the study was the ability of the diets to affect outcomes through appetite regulation. Anthropometric measurements and body composition were assessed at baseline, week 4, and week 26.ResultsIn the study, 465 children (58.1%) completed all assessments. The achieved differences between the GI and protein groups were 2.3 GI U and 4.9 protein percentage points, respectively. The LP/HGI group increased body fat percentage significantly more than the other groups (P = .040; partial η(2) = 0.039), and the percentage of overweight/obese children in the HP/LGI group decreased significantly during the intervention (P = .031).ConclusionsNeither GI nor protein had an isolated effect on body composition. However, the LP/HGI combination increased body fat, whereas the HP/LGI combination was protective against obesity in this sample of children.

28 keywords...

hide…