• Crit Care · Jan 2012

    Editorial Comment

    CXCR3 blockade: a novel anti-sepsis approach?

    • Matthew J Delano and Lyle L Moldawer.
    • Crit Care. 2012 Jan 1;16(6):176.

    AbstractBlockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed.

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