• Acta Neurochir. Suppl. · Jan 2002

    Diffuse brain injury complicated by acute subdural hematoma in the rodents: the effect of early or delayed surgical evacuation.

    • S Sawauchi, A Beaumont, S Signoretti, Y Tomita, C Marmarou, and A Marmarou.
    • Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA.
    • Acta Neurochir. Suppl. 2002 Jan 1;81:243-4.

    AbstractOf all the possible clinical factors affecting the outcome of patients suffering acute subdural hematomas (SDH), timing of surgical evacuation is certainly the most debated. The purpose of this study was to develop an experimental model able to reproduce the clinical behavior of post-traumatic SDH as observed in head injured patients. We present a novel model of SDH combined with diffuse brain injury (DBI), and investigate the effects of early and delayed surgical evacuation. Following Impact Acceleration DBI, adult Sprague-Dawley rats were given a 400 microliters SDH. Hematoma was then evacuated at one (rapid evacuation) or four hours (delayed evacuation) post-injury. Physiological parameters were measured for 5 hours, followed by the assessment of brain water content. In this experimental model, there is strong evidence that trauma acts synergistically with SDH enhancing brain edema formation and increasing ICP. In absence of secondary insult, rapid evacuation of traumatic SDH limits exposure to high ICP, reduces brain edema and is beneficial.

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