• Clinics in chest medicine · Dec 2008

    Review

    Cellular dysfunction in sepsis.

    • Mervyn Singer.
    • University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK. m.singer@ucl.ac.uk
    • Clin. Chest Med. 2008 Dec 1;29(4):655-60, viii-ix.

    AbstractCellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availability appears to trigger a metabolic shutdown that impairs normal functioning of the cell. This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors.

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