• Int. J. Cardiol. · Apr 2007

    Letter Case Reports

    Neonatal life-threatening arrhythmia responding to lidocaine, a probable LQTS3.

    • Pedro Betrián Blasco, María Isabel Antúnez Jiménez, Luis Hipólito Falcón González, and Pedro Suárez Cabrera.
    • Int. J. Cardiol. 2007 Apr 25;117(2):e61-3.

    AbstractIntrauterine and neonatal manifestations of congenital long QT syndrome (LQTS) are associated with a high cardiac risk. We present a newborn, with antecedents of intrauterine premature ventricular contractions, showing in his surface electrocardiogram (ECG): a QTc of 0.69 ms, 2:1 atrioventricular block, autolimited episodes of ventricular tachycardia and Torsade de Pointes. Intravenous esmolol therapy was started, being only partially effective. Because of the ECG phenotype, a LQTS3 is suspected, and intravenous lidocaine was started, achieving sinus rhythm, a normal QTc and no new episodes of ventricular tachycardia. Lidocaine was substituted for oral mexiletine, and esmolol for propranolol. During the follow-up the patient has remained asymptomatic under therapy with propranolol and mexiletine.

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