• J Dermatolog Treat · Apr 2004

    Clinical Trial Controlled Clinical Trial

    Study on the efficacy of ELA-Max (4% liposomal lidocaine) compared with EMLA cream (eutectic mixture of local anesthetics) using thermosensory threshold analysis in adult volunteers.

    • M B Y Tang, A T J Goon, and C L Goh.
    • National Skin Centre, Singapore. marktang@nsc.gov.sg
    • J Dermatolog Treat. 2004 Apr 1;15(2):84-7.

    BackgroundELA-Max and EMLA cream are topical anesthetics that have been shown to have similar anesthetic efficacy in previous studies.ObjectiveTo evaluate the analgesic efficacy of ELA-Max in comparison with EMLA cream using a novel method of thermosensory threshold analysis.MethodsA thermosensory analyzer was used to assess warmth- and heat-induced pain thresholds.ResultsNo statistically significant difference was found in pain thresholds using either formulation. However, EMLA cream increased the heat-induced pain threshold to a greater extent than ELA-Max. Thermosensory measurement and analysis was well tolerated and no adverse events were encountered.ConclusionsEMLA cream may be superior to ELA-Max for heat-induced pain. This study suggests that thermosensory measurement may be another suitable tool for future topical anesthetic efficacy studies.

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