• Nawel Meskine, Marie-Pierre Vullierme, Magaly Zappa, Gaspard d'Assignies, Annie Sibert, and Valérie Vilgrain.
• Assistance Publique des Hôpitaux de Paris, APHP, Department of Radiology, Hôpital Beaujon, 100 bd du Général Leclerc 92110 Clichy, France.
• Acad Radiol. 2011 Jul 1;18(7):816-21.

Rationale And ObjectivesPercutaneous liver biopsy for tumors performed under local anesthesia is still a painful procedure. The aim of this study was to evaluate the patient's reaction and the analgesic efficacy and safety of an equimolar mixture of oxygen and nitrous oxide (EMONO) inhalation.Materials And MethodsA monocenter, prospective, randomized and double-blind controlled study was performed including 99 adult patients undergoing ultrasound controlled liver biopsy for tumors. 50 patients received an EMONO and 49 patients received a placebo. Pain was evaluated by patients before and after the procedure using a Visual Analog Scale.ResultsAnalgesic control, defined by the difference between the final and initial VAS scores (Δ), was significantly better in the EMONO group than in the placebo group (Δ = 17.8 ± 25.5 mm vs 30.1 ± 32.6 mm; P = .045. The number of patients who would agree to undergo another liver biopsy under the same conditions was significantly higher in the EMONO group than the placebo group (92.0% vs 75.5%, P = .026). There were no side-effects from the administration of an EMONO.ConclusionThis study shows that patients receiving an EMONO had a higher analgesic control after percutaneous biopsy of focal liver lesions than patients in the placebo group. Moreover, acceptance of additional biopsies was higher in the EMONO group.Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved.

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