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Actas Dermosifiliogr · May 2013
Case ReportsSulfasalazine-induced linear immunoglobulin A bullous dermatosis with DRESS.
- N Hernández, L Borrego, E Soler, and J Hernández.
- Servicio de Dermatología, Complejo Hospitalario Universitario Insular Materno Infantil de Gran Canaria, Las Palmas, Spain. noheh@hotmail.com
- Actas Dermosifiliogr. 2013 May 1;104(4):343-6.
AbstractLinear immunoglobulin (Ig) A dermatosis is an immune-mediated bullous disease characterized by linear deposits of IgA along the basal membrane. While usually idiopathic, it can occasionally be induced by drug exposure. We report the case of a 60-year-old woman with rheumatoid arthritis being treated with sulfasalazine who developed linear IgA dermatosis and drug rash with eosinophilia and systemic symptoms (DRESS). The dermatosis and associated symptoms resolved following withdrawal of the drug and treatment with systemic corticosteroids for 2 months. This is the first report of sulfasalazine-induced linear IgA dermatosis in association with DRESS and we believe that sulfasalazine should be added to the list of drugs that can cause linear IgA dermatosis.Copyright © 2011 Elsevier España, S.L. and AEDV. All rights reserved.
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