• Florian Morazin, Agnès Lumbroso, Patrick Harry, Marcel Blaise, Alain Turcant, Philippe Montravers, and Rémy Gauzit.
• Département d'Anesthésie-Réanimation, CHU Jean Verdier--Assistance Publique Hôpitaux de Paris, Bondy Cedex, France.
• Clin Toxicol (Phila). 2007 Oct 1;45(7):794-7.

BackgroundTo describe a profound cardiac dysfunction and a status epilepticus after a massive bupropion overdose.Case ReportA 35-year-old man was admitted in coma following the deliberate ingestion of 12 g of bupropion. The course was marked by the rapid onset of severe and prolonged status epilepticus and cardiogenic shock. Plasma bupropion level determined four hours after the estimated time of ingestion was 1.4 mg/L. All clinical features resolved completely in response to symptomatic treatment.ConclusionSeveral cases of bupropion overdose, with sinus tachycardia and seizures rapidly corrected by symptomatic treatment, have been reported in the literature. To our knowledge, this case of overdose with bupropion alone, at very high doses, is the first to describe clinical features comprising severe and prolonged status epilepticus and direct cardiotoxicity with the development of cardiogenic shock documented by echocardiogram.

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