• Sheng-Fu Liang, Fu-Zen Shaw, Chung-Ping Young, Da-Wei Chang, and Yi-Cheng Liao.
• Department of Computer Science and Information Engineering & the Institute of Medical Informatics, National Cheng Kung University, Tainan 701, Taiwan. sfliang@mail.ncku.edu.tw
• Conf Proc IEEE Eng Med Biol Soc. 2010 Jan 1;2010:4950-3.

AbstractThe worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-99% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.

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