• Lisa Barbera, Hsien Seow, Doris Howell, Rinku Sutradhar, Craig Earle, Ying Liu, Audra Stitt, Amna Husain, Jonathan Sussman, and Deborah Dudgeon.
• Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. lisa.barbera@sunnybrook.ca
• Cancer. 2010 Dec 15;116(24):5767-76.

BackgroundFor ambulatory cancer patients, Ontario has standardized symptom and performance status assessment population-wide, using the Edmonton Symptom Assessment System (ESAS) and Palliative Performance Scale (PPS). In a broad cross-section of cancer outpatients, the authors describe the ESAS and PPS scores and their relation to patient characteristics.MethodsThis is a descriptive study using administrative healthcare data.ResultsThe cohort included 45,118 and 23,802 patients' first ESAS and PPS, respectively. Fatigue was most prevalent (75%), and nausea least prevalent (25%) in the cohort. More than half of patients reported pain or shortness of breath; about half of those reported moderate to severe scores. Seventy-eight percent had stable performance status scores. On multivariate analysis, worse ESAS outcomes were consistently seen for women, those with comorbidity, and those with shorter survivals from assessment. Lung cancer patients had the worst burden of symptoms.ConclusionsThis is the first study to report ESAS and PPS scores in a large, geographically based cohort with a full scope of cancer diagnoses, including patients seen earlier in the cancer trajectory (ie, treated for cure). In this ambulatory cancer population, the high prevalence of numerous symptoms parallels those reported in palliative populations and represents a target for improved clinical care. Differences in outcomes for subgroups require further investigation. This research sets the groundwork for future research on patient and provider outcomes using linked administrative healthcare data.Copyright © 2010 American Cancer Society.

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