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Randomized Controlled Trial Clinical Trial
Effect of fresh gas flow on isoflurane concentrations during low-flow anaesthesia.
- J-Y Park, J-H Kim, W-Y Kim, M-S Chang, J-Y Kim, and H-W Shin.
- Department of Anaesthesiology, Korea University Anam Hospital, Seoul, Korea.
- J. Int. Med. Res. 2005 Sep 1;33(5):513-9.
AbstractThe effect of fresh gas flow (FGF) on isoflurane concentrations at given vaporizer settings during low-flow anaesthesia was investigated. Ninety patients (American Society of Anaesthesiologists physical status I or II) were randomly allocated to three groups (FGF 1 l/min, FGF 2 l/min and FGF 4 l/min). Anaesthesia was maintained for 10 min with vaporizer setting isoflurane 2 vol% and FGF 4 l/min for full-tissue anaesthetic uptake in a semi-closed circle system. Low-flow anaesthesia was maintained for 20 min with end-tidal isoflurane 1.5 vol% and FGF 2 l/min. FGF was then changed to FGF 1 l/min, FGF 2 l/min or FGF 4 l/min. Measurements during the 20-min period showed that inspired and end-tidal isoflurane concentrations decreased in the FGF 1-l/min group but increased in the FGF 4-l/min group compared with baseline values. No haemodynamic changes were observed. Monitoring of anaesthetic concentrations and appropriate control of vaporizer settings are necessary during low-flow anaesthesia.
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