• M Shrestha, D L Morgan, J M Moreden, R Singh, M Nelson, and J E Hayes.
• Division of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
• Ann Emerg Med. 1995 Dec 1;26(6):682-6.

Study ObjectiveTo compare the analgesic effect of IM ketorolac tromethamine with that of oral indomethacin in the treatment of acute gouty arthritis.DesignProspective, randomized, double-blind, controlled, parallel group clinical trial.SettingTwo urban emergency departments.ParticipantsTwenty consecutive patients who presented to the ED with acute gout.InterventionsEach patient was randomly assigned to receive in the ED (1) 60 mg of IM ketorolac and oral placebo or (2) 50 mg of oral indomethacin and IM placebo. The patients rated the intensity of their pain on a Wong-Baker pain scale (which runs from 0 to 5) before treatment and 30, 60, 90, and 120 minutes after treatment. All the patients were discharged with instructions to take oral indomethacin and to complete pain score cards at home at 6, 12, and 24 hours.ResultsThe 10 patients in each group were similar with regard to age, sex, race, and initial mean pain score. After 2 hours, the mean pain scores (+/- SD) for the ketorolac group had decreased from 4.5 +/- .71 to 1.4 +/- 1.43 (P < .05), and the mean score for the indomethacin group had decreased from 4.4 +/- .70 to 1.5 +/- 1.18 (P < .05). The difference between the two groups was not significant. At 6 hours, there was some pain rebound in the ketorolac group.ConclusionIM ketorolac and oral indomethacin are similar in the relief of the pain of acute gouty arthritis in the ED.

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