• I Younis and R P Bhutiani.
• Day Surgery Unit, Northwick Park and St Mark's Hospitals, Harrow, UK.
• Ann R Coll Surg Engl. 2004 May 1;86(3):213-7.

AimsTo compare the effect of buffered commercial 1% xylocaine (with 1:200,000 adrenaline) and the unbuffered commercial 1% xylocaine (with 1:200,000 adrenaline) preparation on pain during infiltration and procedure.Patients And MethodsA randomised, double blind controlled trial involving 85 patients who underwent bilateral vasectomy under local infiltration anaesthesia.ResultsEach patient served as his own control by receiving the buffered commercial preparation on one side and unbuffered commercial preparation on the other. Linear analogue pain scores during infiltration and procedure were recorded and analysed. The study demonstrated that pain perceived by the patient both during infiltration and the procedure was significantly lower when buffered commercial xylocaine was used as compared to the pain perceived with the use of unbuffered commercial xylocaine.ConclusionsUse of buffered xylocaine is a simple, inexpensive and significantly effective way of reducing pain during infiltration and in surgical procedures performed under local anaesthesia.

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