• Robert West, Amadeo Pesce, Cameron West, Bridgit Crews, Charles Mikel, Murray Rosenthal, Perla Almazan, and Sergey Latyshev.
• Millennium Laboratories, San Diego, California, USA.
• J Opioid Manag. 2010 Jul 1;6(4):253-7.

BackgroundOne of the major concerns of physicians treating pain patients with opioids is to determine whether the patients are compliant, and this is commonly determined by urine drug testing. There is limited information on which drugs these patients are most compliant with. There is also limited information as to how compliance is defined in terms of cutoffs.ObjectiveTo compare reported patient medication use with the presence of the drug in the patients' urine with defined cutoffs.MethodA retrospective study of the medications listed by the physicians' offices and the confirmed drug test findings. A Millennium Laboratories database of 20, 457 patient results was examined for the presence of the listed medications and was matched for the presence of the drugs above the analytical cutoffs.ResultsFor oxycodone and hydrocodone, the authors observed 23 and 24 percent noncompliance, respectively. For carisoprodol, they observed 33 percent noncompliance. For morphine, they observed 14 percent noncompliance. For methadone, they observed 9 percent noncompliance.ConclusionsNoncompliance is prevalent in this patient population and varies with the prescribed drug.

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