• Clinics in chest medicine · Jun 2011

    Review

    Primary graft dysfunction.

    • James C Lee and Jason D Christie.
    • Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. james.lee@uphs.upenn.edu
    • Clin. Chest Med. 2011 Jun 1;32(2):279-93.

    AbstractPrimary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment.Copyright © 2011 Elsevier Inc. All rights reserved.

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