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- Christine Winter and Georg Herrler.
- Institut für Virologie der Tierärztliche Hochschule Hannover. christine.winter@tiho-hannover.de
- Berl Munch Tierarztl. 2013 Nov 1;126(11-12):509-13.
AbstractThe outbreak of the SARS coronavirus in 2002/2003 and the recent disease cases with a new human coronavirus (originally designated EMC-CoV, recently renamed MERS-CoV) have put the focus onto the virus family Coronaviridae. Both viruses appeared to have managed to jump over the species barrier from a bat reservoir to the human population. Bats are considered to serve as a natural reservoir for coronaviruses infecting mammals. An important factor for crossing the species-barrier is the adaptation to a new receptor on cells of the new host species. During evolution coronaviruses have developed a large diversity of binding specificities demonstrating the high flexibility of the coronaviral spike protein, which is responsible for binding to target cells.
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