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Critical care clinics · Jul 1991
ReviewToxic effects of drugs used in the ICU. Nitroprusside, nitroglycerin, and angiotensin-converting enzyme inhibitors.
- S C Curry and P Arnold-Capell.
- Good Samaritan Regional Medical Center, Phoenix Children's Hospital, Arizona.
- Crit Care Clin. 1991 Jul 1;7(3):555-81.
AbstractSodium nitroprusside causes cyanide poisoning at currently recommended infusion rates. Serum thiocyanate concentrations are of no value in detecting cyanide poisoning caused by nitroprusside. Methemoglobinemia in those patients receiving intravenous nitroglycerin may seriously impair oxygen delivery and is not always accompanied by cyanosis in anemic patients. Angiotensin-converting enzyme inhibitors are responsible for a plethora of adverse effects, including renal insufficiency, hypotension, angioedema, cough, and increased insulin sensitivity.
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