• D Kaski, R O Dominguez, J H Allum, A F Islam, and A M Bronstein.
• Division of Brain Sciences, Imperial College London, London, UK Universidad de Buenos Aires, Hospital Sirio Libanés Buenos Aires, Buenos Aires, Argentina d.kaski@imperial.ac.uk.
• Clin Rehabil. 2014 Nov 1;28(11):1115-24.

ObjectiveTo improve gait and balance in patients with Parkinson's disease by combining anodal transcranial direct current stimulation with physical training.DesignIn a double-blind design, one group (physical training; n = 8) underwent gait and balance training during transcranial direct current stimulation (tDCS; real/sham). Real stimulation consisted of 15 minutes of 2 mA transcranial direct current stimulation over primary motor and premotor cortex. For sham, the current was switched off after 30 seconds. Patients received the opposite stimulation (sham/real) with physical training one week later; the second group (No physical training; n = 8) received stimulation (real/sham) but no training, and also repeated a sequential transcranial direct current stimulation session one week later (sham/real).SettingHospital Srio Libanes, Buenos Aires, Argentina.SubjectsSixteen community-dwelling patients with Parkinson's disease.InterventionsTranscranial direct current stimulation with and without concomitant physical training.Main MeasuresGait velocity (primary gait outcome), stride length, timed 6-minute walk test, Timed Up and Go Test (secondary outcomes), and performance on the pull test (primary balance outcome).ResultsTranscranial direct current stimulation with physical training increased gait velocity (mean = 29.5%, SD = 13; p < 0.01) and improved balance (pull test: mean = 50.9%, SD = 37; p = 0.01) compared with transcranial direct current stimulation alone. There was no isolated benefit of transcranial direct current stimulation alone. Although physical training improved gait velocity (mean = 15.5%, SD = 12.3; p = 0.03), these effects were comparatively less than with combined tDCS + physical therapy (p < 0.025). Greater stimulation-related improvements were seen in patients with more advanced disease.ConclusionsAnodal transcranial direct current stimulation during physical training improves gait and balance in patients with Parkinson's disease. Power calculations revealed that 14 patients per treatment arm (α = 0.05; power = 0.8) are required for a definitive trial.© The Author(s) 2014.

33 keywords...

hide…