• Isao Fukuda, Yoshitaka Uchihashi, Marimo Kira, Takahiro Ogura, Masaaki Shizukuishi, Tomiei Kazama, and Yoshiaki Sugiura.
• Department of Anesthesiology, National Defense Medical College, Tokorozawa.
• Masui. 2005 Jul 1;54(7):736-41.

BackgroundWe performed a comparative study of propofol versus isoflurane and sevoflurane using continuous monitoring of hepatic venous oxygen saturation (ShvO2) during upper abdominal surgery in 26 patients.MethodsAnesthesia was induced with propofol 2-2.5 mg x kg(-1) and vecuronium 0.1 mg x kg(-1). Thereafter, Swan Ganz catheters were inserted into the pulmonary artery and hepatic vein. Group P (n=26) patients received continuous propofol infusion and epidural mepivacaine injection for maintenance, while Group I (n=17) received isoflurane and Group S (n=9) received sevoflurane. Systemic oxygen extraction ratio (OERsys) and hepato-splanchnic oxygen extraction ratio (OERspl) were calculated.ResultsHeart rate, mean arterial pressure and cardiac index were unchanged after propofol infusion, and isoflurane or sevoflurane inhalation. Propofol at 8 and 10 mg x kg(-1) x h(-1) significantly decreased ShvO2 and increased OERspl, although isoflurane and sevoflurane did not change them. Mixed venous saturation and OERsys were within normal ranges during the studies.ConclusionsThe results suggest that propofol increases the metabolism and oxygen consumption in the liver.

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