• Victoria L Woo, Regina Landesberg, Erik A Imel, Steven R Singer, Andrew L Folpe, Michael J Econs, Taeyun Kim, Lara R Harik, and Thomas P Jacobs.
• Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, NV 89106, USA. victoria.woo@unlv.edu
• Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec 1;108(6):925-32.

AbstractTumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that results in renal phosphate wasting with hypophosphatemia. In most cases, the underlying cause of TIO is a small mesenchymal neoplasm that is often difficult to detect, resulting in delayed diagnosis. One such neoplasm is the phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT), an unusual entity with unique morphologic and biochemical features. Most of these tumors are found at appendicular sites with only rare cases reported in the jaws. We describe a PMTMCT involving the mandible in a patient with a protracted history of osteomalacia. A review of the current literature is provided with emphasis on the clinical and histologic features, etiopathogenesis, and management of PMTMCT in the setting of TIO.

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