• C W Reid, P D Slinger, and S Lenis.
• Department of Anesthesia, University of Toronto, Ontario, Canada.
• J. Cardiothorac. Vasc. Anesth. 1996 Dec 1;10(7):860-3.

ObjectiveTo determine whether intravenous propofol-alfentanil anesthesia provides superior arterial oxygenation (Pao2) during one-lung ventilation (OLV) compared with isoflurane inhalation anesthesia.DesignA prospective, randomized, cross-over study.SettingTertiary-care university hospital.ParticipantsThirty adults having either thoracoscopic pulmonary surgery or esophageal surgery.InterventionsPatients received either propofol-alfentanil infusion anesthesia or one minimum alveolar concentration (MAC) of isoflurane during the initial period of two-lung ventilation and the first 30 minutes of OLV and then were switched to the other anesthetic for the duration of OLV.Measurements And Main ResultsArterial blood gases and hemodynamics were recorded during two-lung ventilation and after 20 and 30 minutes of OLV with each anesthetic technique. The mean values (+/- SD) for Pao2 during propofol-alfentanil anesthesia after 20 minutes (222 +/- 100) and 30 minutes (228 +/- 102 mmHg) of one-lung ventilation were not significantly different than after 20 minutes (213 +/- 99) or 30 minutes (214 +/- 96 mmHg) of isoflurane; beta error less than 0.1. Mean heart rate was lower during intravenous (78 +/- 15 min) than inhalation (85 +/- 17 min) anesthesia (rho = 0.03).ConclusionThis study does not support the theory that total intravenous anesthesia will decrease the risk of hypoxemia during OLV.

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