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- Y Horimoto, I Aiba, T Yasuda, Y Ohkawa, T Katayama, Y Yokokawa, A Goto, and Y Ito.
- Department of Neurology, Higashi Nagoya National Hospital, 5-101 Umemorizaka, Meito, Nagoya, Japan. holly@amitaj.or.jp
- J. Neurol. Sci. 2000 Feb 15;173(2):109-12.
AbstractCranial magnetic resonance images (MRI) of the cerebral areas of 40 patients with multiple system atrophy (MSA) and of 61 age-matched controls were analyzed. The cerebral area of MSA patients was 131. 95+/-15.89 cm(2) (mean+/-S.D.), which was significantly smaller than that of normal controls at 149.01+/-10.93 cm(2) (P<0.0001). All 23 MSA cases subjected to the MRI study over a 1-year period showed progressive cerebral atrophy, and the atrophy rate was 2.46+/-1. 66%/year. There were no significant differences within the MSA subtypes or between gender. The progression of cerebral atrophy in MSA correlated more with duration (r=-0.634) than age (r=-0.421). We conclude that MRI findings throughout the course of MSA suggest progressive cerebral atrophy, which is common in all subtypes and reflects duration of the disease rather than age.
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