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Infect. Dis. Clin. North Am. · Sep 2004
ReviewMacrolides and ketolides: azithromycin, clarithromycin, telithromycin.
- Jerry M Zuckerman.
- Jefferson Medical College, Philadelphia, PA, USA. zuckermj@einstein.edu
- Infect. Dis. Clin. North Am. 2004 Sep 1;18(3):621-49, xi-.
AbstractThe advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse effects of these antimicrobial agents.
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