• J Postgrad Med · Jul 2003

    Randomized Controlled Trial Clinical Trial

    Effect of epidural morphine on minimum alveolar concentration of isoflurane in humans.

    • L Kashyap, D K Pawar, H L Kaul, V K Mohan, and S N Dwivedi.
    • Departments of Anaesthesiology and Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029, India. lokeshkashyap@yahoo.com
    • J Postgrad Med. 2003 Jul 1;49(3):211-3.

    Background And AimsThe anaesthetic potency of volatile anaesthetic agents is measured by the minimum alveolar concentration (MAC) required to suppress response in 50% of subjects. We studied the effect of epidural morphine on MAC of isoflurane in humans.Settings And DesignA prospective single-blind study designed to study the effect of epidural morphine on MAC of isoflurane.Subjects And MethodsForty-eight patients were randomly divided into two groups - Group I patients received 3 mg morphine in 10 ml saline, and Group II patients received 10 ml saline epidurally. Anaesthesia was induced with isoflurane in oxygen and nitrous oxide. Later nitrous oxide was discontinued and MAC of isoflurane determined using modified Dixon's method of sequential sampling.ResultsEpidural morphine resulted in a significant reduction in MAC of isoflurane, 0.98 vs. 1.14 in control group (p<0.05).ConclusionsEpidural administration of 3 mg morphine in 10 ml saline decreased the MAC of isoflurane.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…