• Acta Anaesthesiol Scand Suppl · Jan 1995

    Mivacurium chloride administration by infusion.

    • J L Apfelbaum.
    • Department of Anesthesia and Critical Care, University of Chicago Hospitals, IL 60637, USA.
    • Acta Anaesthesiol Scand Suppl. 1995 Jan 1;106:55-7.

    AbstractAs a consequence of its rapid hydrolysis by plasma cholinesterase, mivacurium has a short duration of action, and recovery from neuromuscular blockade is rapid (5-95% twitch recovery = 13-15 min). Mivacurium is easy to titrate to individual patient requirements; the average infusion rate to maintain neuromuscular blockade at 89-99% twitch suppression during N2O/opioid anaesthesia is 6-7 micrograms/kg per min in adults and approximately 14 micrograms/kg per min in children. There is no evidence of a cumulative effect of mivacurium; recovery is unaffected by dose administered or duration of infusion. These characteristics make mivacurium a very suitable agent for use by infusion.

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