• Curr Pain Headache Rep · Oct 2004

    Review

    Post-triptan era for the treatment of acute migraine.

    • Peter J Goadsby.
    • Institute of Neurology, Queen Square, London WC1N 3BG, UK. peterg@ion.ucl.ac.uk
    • Curr Pain Headache Rep. 2004 Oct 1; 8 (5): 393398393-8.

    AbstractThere now is one realized and several attractive targets for the treatment of acute attacks of migraine that will follow and augment the use of serotonin 5-HT1B/1D receptor agonists, the triptans. Calcitonin gene-related peptide (CGRP) receptor blockade recently has been shown to be an effective acute antimigraine strategy; therefore, blockade of CGRP release by inhibition of trigeminal nerves would seem a logical approach. A number of targets are reviewed in this article including serotonin 5-HT1F and 5-HT1D receptors, adenosine A1 receptors, nociceptin, vanilloid TRPV1 receptors, and anandamide CB1 receptors. Development of one or more such compound offers the exciting prospect of new non-vasoconstrictor treatments for migraine and cluster headache.

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