• David Beckwée, Willem De Hertogh, Pierre Lievens, Ivan Bautmans, and Peter Vaes.
• Vrije Universiteit Brussel, Department of Physiotherapy, Faculty of Physical Education & Physiotherapy, Laarbeeklaan 103, B-1090 Brussels, Belgium. David.Beckwee@vub.ac.be
• Trials. 2012 Jan 1;13:21.

BackgroundCentral sensitization has recently been documented in patients with knee osteoarthritis (OAk). So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing the pain inhibitory effect of tens on osteoarthritis of the knee. The purpose of this study is to explore the pain inhibitory effect of burst tens in OAk patients and to explore the prognostic value of central sensitization on the pain inhibitory effect of tens in OAk patients.MethodsPatients with knee pain due to OAk will be recruited through advertisements in local media. Temporal summation, before and after a heterotopic noxious conditioning stimulation, will be measured. In addition, pain on a numeric rating score, WOMAC subscores for pain and function and global perceived effect will be assessed. Patients will be randomly allocated to one of two treatment groups (tens, sham tens). Follow-up measurements will be scheduled after a period of 6 and 12 weeks.DiscussionTens influences pain through the electrical stimulation of low-threshold A-beta cutaneous fibers. The responsiveness of central pain-signaling neurons of centrally sensitized OAk patients may be augmented to the input of these electrical stimuli. This would encompass an adverse therapy effect of tens. To increase treatment effectiveness it might be interesting to identify a subgroup of symptomatic OAk patients, i.e., non-sensitized patients, who are likely to benefit from burst tens.Trial RegistrationClinicalTrials.gov: NCT01390285.

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