• Life sciences · Jan 1990

    Reduction of T-kininogen messenger RNA levels by dexamethasone in the adjuvant-treated rat.

    • E F Howard, Y G Thompson, C A Lapp, and L M Greenbaum.
    • Department of Cell and Molecular Biology, School of Graduate Studies, Medical College of Georgia, Augusta 30912-2100.
    • Life Sci. 1990 Jan 1;46(6):411-7.

    AbstractWhen inflammation is induced in rats following injection of Freund's complete adjuvant, steady state levels of T-I and T-II kininogen mRNAs increase markedly as do plasma levels of T-I and T-II kininogens. When rats are additionally treated with dexamethasone, T-I and T-II steady state mRNA levels and plasma levels of T-kininogens are reduced. The results suggest that dexamethasone may affect the magnitude of T-kininogen gene induction caused by inflammation.

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