• J. Neuropathol. Exp. Neurol. · May 1995

    Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus.

    • E Galbreath, S J Kim, K Park, M Brenner, and A Messing.
    • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA.
    • J. Neuropathol. Exp. Neurol. 1995 May 1;54(3):339-49.

    AbstractTransforming growth factor beta (TGF-beta) has been proposed to play a number of roles in central nervous system (CNS) development and response to injury. To test these proposals, transgenic mice were generated which overproduce TGF-beta 1 in the CNS. Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age. Ovary transplantation from an affected female founder has permitted perpetuation of one of the lines as a hydrocephalus model whose genetic defect is known. These results also demonstrate that the developing CNS is highly sensitive to TGF-beta, and suggest a role for aberrant expression of TGF-beta in the pathogenesis of developmental disease of the CNS.

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