• Pain · Nov 2010

    Viscero-visceral hyperalgesia: characterization in different clinical models.

    • Maria Adele Giamberardino, Raffaele Costantini, Giannapia Affaitati, Alessandra Fabrizio, Domenico Lapenna, Emmanuele Tafuri, and Andrea Mezzetti.
    • Department of Medicine and Science of Aging, G. D'Annunzio University of Chieti, Italy. mag@unich.it
    • Pain. 2010 Nov 1;151(2):307-22.

    AbstractCo-existing algogenic conditions in two internal organs in the same patient may mutually enhance pain symptoms (viscero-visceral hyperalgesia). The present study assessed this phenomenon in different models of visceral interaction. In a prospective evaluation, patients with: (a) coronary artery disease (CAD)+gallstone (Gs) (common sensory projection: T5); (b) irritable bowel syndrome (IBS)+dysmenorrhea (Dys) (T10-L1); (c) dysmenorrhea/endometriosis+urinary calculosis (Cal)(T10-L1); and (d) gallstone+left urinary calculosis (Gs+LCal) (unknown common projection) were compared with patients with CAD, Gs, IBS, Dys or Cal only, for spontaneous symptoms (number/intensity of pain episodes) over comparable time periods and for referred symptoms (muscle hyperalgesia; pressure/electrical pain thresholds) from each visceral location. In patients' subgroups, symptoms were also re-assessed after treatment of each condition or after no treatment. (a) CAD+Gs presented more numerous/intense angina/biliary episodes and more referred muscle chest/abdominal hyperalgesia than CAD or Gs; cardiac revascularization or cholecystectomy also reduced biliary or cardiac symptoms, respectively (0.001Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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