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Nan Fang Yi Ke Da Xue Xue Bao · Jun 2009
Randomized Controlled Trial[Effect of propofol and isoflurane on surgical stress response and postoperative cognitive function in elderly patients].
- Rong Tan.
- Department of Anesthesiology, Xiangya Second Hospital, Central South University, Changsha, China.
- Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun 1;29(6):1247-8.
ObjectiveTo investigate the effect of propofol and isoflurane on surgical stress response and postoperative cognitive function in elderly patients.MethodsSixty elderly patients scheduled for elective upper abdominal surgery with general anesthesia were randomized equally into propofol group and isoflurane group. The surgical stress response, postoperative Mini-mental State Examination (MMSE) and the rate of postoperative cognitive dysfunction (POCD) were compared between the two groups.ResultsThe surgical stress response in propofol group was relatively stable. Compared with isoflurane group, the patients in propofol group showed significantly faster recovery of the MMSE scores with also lower rate of POCD.ConclusionCompared with isoflurane, propofol intravenous anesthesia is associated with rapid recovery of the cognitive function, stable surgical stress response and reduced adverse effects in elderly patients.
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