• Acta paediatrica · Dec 2012

    Limitations of the risk factor based approach in early neonatal sepsis evaluations.

    • Orna Flidel-Rimon, Sophie Galstyan, Ada Juster-Reicher, Ilya Rozin, and Eric S Shinwell.
    • Department of Neonatology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University, Jerusalem, Israel. orna_f@clalit.org.il
    • Acta Paediatr. 2012 Dec 1;101(12):e540-4.

    AimGuidelines for detection of early neonatal sepsis employ a risk factor approach combined with laboratory parameters. In an era of increasing intrapartum antibiotic prophylaxis (IAP), we re-assessed the approach as a whole and each of the risk factors individually.MethodThis retrospective study included infants with risk factors for sepsis or those treated with antibiotics or who had documented early sepsis. Safety of the protocol was assessed by the number of cases of either missed or partially treated late sepsis or meningitis and the sepsis-related mortality rate. Predictive value of each clinical and laboratory factor was calculated.ResultsOf the 22,215 neonates, 2096 were assessed. IAP among infants with risk factors rose from 68% in 2005 to 78% in 2008 (p = 0.001). A total of 1662 asymptomatic infants had risk factors, 635 received antibiotics and one (0.06%) had sepsis. A total of 434 symptomatic infants were treated with antibiotics and of these 234 had risk factors and 20 (4.6%) had sepsis. No cases of partially treated or missed sepsis were detected. Poor predictive value was found for all risk factors except prematurity and leukopenia.ConclusionThe risk factor based approach in asymptomatic infants cannot be justified. In-hospital observation of asymptomatic infants for 2-3 days with antibiotic treatment being reserved only for symptomatic infants may be a reasonable alternative.© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

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