• Transpl Infect Dis · Apr 2010

    Case Reports

    Influenza A/H1N1 2009 pneumonia in kidney transplant recipients: characteristics and outcomes following high-dose oseltamivir exposure.

    • S P Watcharananan, T Suwatanapongched, P Wacharawanichkul, W Chantratitaya, V Mavichak, and S B Mossad.
    • Department of Infectious Disease, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. orndoctor@yahoo.com
    • Transpl Infect Dis. 2010 Apr 1;12(2):127-31.

    AbstractWe report 2 cases of severe pneumonia due to the novel pandemic influenza A/H1N1 2009 in kidney transplant recipients. Our patients initially experienced influenza-like illness that rapidly progressed to severe pneumonia within 48 h. The patients became hypoxic and required non-invasive ventilation. The novel influenza A/H1N1 2009 was identified from their nasal swabs. These cases were treated successfully with a relatively high dose of oseltamivir, adjusted for their renal function. Clinical improvement was documented only after a week of antiviral therapy. Despite early antiviral treatment, we showed that morbidity following novel pandemic influenza A/H1N1 2009 infection is high among kidney transplant recipients.

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