• Curr Opin Crit Care · Aug 2010

    Review

    Fluid therapy in septic shock.

    • Emanuel P Rivers, Anja Kathrin Jaehne, Laura Eichhorn-Wharry, Samantha Brown, and David Amponsah.
    • Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, Michigan, USA. erivers1@hfhs.org
    • Curr Opin Crit Care. 2010 Aug 1;16(4):297-308.

    Purpose Of ReviewTo examine the role of fluid therapy in the pathogenesis of severe sepsis and septic shock. The type, composition, titration, management strategies and complications of fluid administration will be examined in respect to outcomes.Recent FindingsFluids have a critical role in the pathogenesis and treatment of early resuscitation of severe sepsis and septic shock.SummaryAlthough this pathogenesis is evolving, early titrated fluid administration modulates inflammation, improves microvascular perfusion, impacts organ function and outcome. Fluid administration has limited impact on tissue perfusion during the later stages of sepsis and excess fluid is deleterious to outcome. The type of fluid solution does not seem to influence these observations.

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