• Neurology · Jan 2006

    Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS.

    • F Kimura, C Fujimura, S Ishida, H Nakajima, D Furutama, H Uehara, K Shinoda, M Sugino, and T Hanafusa.
    • Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Osaka, Japan. in1110@poh.osaka-med.ac.jp
    • Neurology. 2006 Jan 24;66(2):265-7.

    AbstractThe authors calculated the progression rate (DeltaFS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the DeltaFS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the DeltaFS provides an additional predictive index beyond ALSFRS-R alone.

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