• Scott A Handley, Larissa B Thackray, Guoyan Zhao, Rachel Presti, Andrew D Miller, Lindsay Droit, Peter Abbink, Lori F Maxfield, Amal Kambal, Erning Duan, Kelly Stanley, Joshua Kramer, Sheila C Macri, Sallie R Permar, Joern E Schmitz, Keith Mansfield, Jason M Brenchley, Ronald S Veazey, Thaddeus S Stappenbeck, David Wang, Dan H Barouch, and Herbert W Virgin.
• Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
• Cell. 2012 Oct 12;151(2):253-66.

AbstractPathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.Copyright © 2012 Elsevier Inc. All rights reserved.

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