• Augusto M Lorenzutti, Manuel Martin-Flores, Juan M Baldivieso, Martín A Himelfarb, and Nicolás J Litterio.
• Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
• Can Vet J. 2014 Feb 1;55(2):156-60.

AbstractResidual neuromuscular block (NMB) during recovery from general anesthesia may be minimized by antagonizing NMB with neostigmine. We examined neostigmine for restoring neuromuscular function when administered at 2 levels of vecuronium-induced NMB in dogs. Eight healthy adult dogs received vecuronium 0.1 mg/kg body weight (BW), IV, during isoflurane anesthesia. Recovery from vecuronium occurred spontaneously (control group; C), or was enhanced with neostigmine, 0.04 mg/kg BW, IV, administered when 2 (N2) or 4 (N4) responses to train-of-four (TOF) stimulation were first observed. Duration of NMB was significantly shorter for N2 and N4 than for C. The period of complete NMB was equal for all groups; differences were observed during the recovery phase of NMB. Time of neostigmine-enhanced recovery was significantly shorter for N4 than N2, but overall duration of NMB was not reduced. Recovery from NMB was faster with neostigmine. There is no clinical advantage in delaying neostigmine administration once 2 responses to TOF are present.

17 keywords...

hide…